• Osetocyte cells (large blue globs) and their expansive network of dendritic processes

(F ² Lab)

Our goals are directed toward investigating the mechanisms of deformation, fracture, and the biological responses in biological materials at multiple length-scales (from molecular to macroscales). Our work aims at bridging the gap between mechanics of materials, biology, and experimental high-energy x-ray physics to understand skeletal biology and disease as well as design principles behind biomaterials.

Affiliated with the Departments of Mechanical Engineering and Biomedical Engineering at the University of Utah, the Fracture and Fatigue of Skeletal Tissues Laboratory is directed by Dr. Claire Acevedo.

The Fracture and Fatigue of Skeletal Tissues Lab’s research is currently funded by the National Science Foundation, National Institutes of Health, the Advanced Light Source, the University of Utah Center on Aging, and the National Institute for Occupational Safety & Health.



PAPER ACCEPTED in Communications Materials – Nature! Authored by Mike and Yoshi, this work highlights the use of deep learning for in situ synchrotron mechanical testing of bone (READ MORE)

Michael Sieverts presented at IEEE eScience right here in SLC! There, he talked about a technique for analyzing multiple tissues in synchrotron micro-CT images.

ALICE L. JEE Award was awarded to Dr. Acevedo at the 2022 Orthopaedic Research Society Musculoskeletal Biology Workshop. Dr. Acevedo presented the F² Lab’s recent work on the effect of diabetes on bone material properties and microstructure. Congrats!

YOSHI OBATA presented again at SB³C (Summer Biomechanics, Bioengineering, and Biotransport Conference) this year, this time about how a high-fat diet affects bone microstructure and nanostructure! Big thanks to the Alliston Lab at UCSF, who we collaborated with for this study.

WILLIAM WOOLLEY gave a thought-provoking talk at BONITOS in New York! He presented about the whole-bone mechanical properties of rat bone with type 2 diabetes as well as changes in their microstructure.

CONGRATS JAMES on a wonderful presentation at ORS! James presented on the effects of type 2 diabetes on vertebral discs in rats. He highlighted advanced synchrotron small-angle x-ray scattering experiments performed at the Advanced Light Source. Bravo!

WELCOME IHSAN to the F² Lab! Ihsan will be working as a Master student on microscale and nanoscale material properties of structures in bone. Find out more about him at this link! (READ MORE)

NIH R21 Grant Awarded to Dr. Acevedo! The National Institutes of Health Exploratory/Developmental R21 grant was awarded to Dr. Acevedo to research the mechanisms of increased fracture risk in diabetic bone at the collagen molecular level. (READ MORE)

NSF CAREER GRANT AWARDED to Dr. Acevedo! The National Science Foundation Faculty Early Career Development Program (CAREER) award is a prestigious 5-year award offering 5 years of funding for early-career faculty. Congrats! (READ MORE)